G proteins of the G₁₂ family expressed by POMC neurons regulate key metabolic functions.

ABSTRACT: Proopiomelanocortin (POMC) neurons play a key role in maintaining glucose and energy homeostasis. POMC neurons express many heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors that are linked to different functional classes of G proteins. The potential role of G_12/13 in regulating the function of central POMC neurons remains unknown. To address this question, we used a chemogenetic approach to selectively stimulate G_12/13 signaling in POMC neurons. We found that receptor-mediated activation of G_12/13 signaling in POMC neurons caused notable improvements in glucose homeostasis in lean and obese mice. Stimulation of G_12/13 signaling in POMC neurons also enhanced the physiological actions of leptin. Studies with G_12/

SUBMITTER: Haspula D 

PROVIDER: S-EPMC12248387 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature