Zinc Finger Protein-Based Prognostic Signature Predicts Survival in Lung Adenocarcinoma.

ABSTRACT: Background: Zinc finger proteins (ZNFs), functioning as pervasive transcriptional modulators, serve as pivotal mediators of tumorigenesis and malignant advancement. However, the mechanistic contributions of these epigenetic orchestrators to lung adenocarcinoma pathogenesis remain incompletely characterized. Methods: To elucidate zinc finger proteins' biological significance in lung adenocarcinoma (LUAD) pathogenesis, we first extracted relevant transcriptional data from TCGA. After preliminary screening with univariate Cox regression, a LASSO algorithm was applied to optimize the risk score model, incorporating key zinc finger protein markers. For independent validation, we accessed GEO dataset GSE68465, applying identical analytical protocols to confirm model generalizabilit

SUBMITTER: Yu L 

PROVIDER: S-EPMC12248513 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature