Preliminary Study on PCC-Chitosan's Ability to Enhance Microplastic Excretion in Human Stools from Healthy Volunteers.

ABSTRACT: Recent studies have indicated that microplastics (MPs) may accumulate in the human body, potentially posing health risks. This preliminary study aimed to investigate the effect of a food supplement (FS: 0.8 g of chitosan derived from Procambarus clarkii, PCC) on the fecal excretion of MPs (20-500 µm size) following ingestion of a standardized meal (SM). Ten healthy volunteers (non-smokers, non-drinkers, non-drug users) participated in a two-phase, crossover design conducted one week apart. In both phases, participants consumed an SM after overnight fasting, and fecal samples were collected the following morning (7-10 am). Phase 1 served as baseline (no PCC), while in Phase 2, PCC was administered immediately before the SM. Sixteen types of MPs were analyzed. A modest increase (5%) i

SUBMITTER: Casella C 

PROVIDER: S-EPMC12248620 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature