Using [¹⁸F]FDG PET/CT to Identify Optimal Responders to Neoadjuvant Therapy in Breast Cancer-Results from a Prospective Patient Cohort.

ABSTRACT: Background/objectives: Pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) in breast cancer (BC) is a solid indicator of favourable prognosis, potentially also being useful for more conservative patient management. We aim to explore the potential of [¹⁸F]FDG PET/CT as a non-invasive method to predict response to NAC. Methods: In this prospective, observational cohort study, we enrolled BC patient candidates for NAC who underwent baseline and preoperative [¹⁸F]FDG PET/CT. NAC response was determined using final histopathology. PET images were assessed qualitatively and semi-quantitatively, and the findings correlated with NAC response. Results: In total, 133 BC patients were included. The visual analysis of preoperative PET/CT de

SUBMITTER: Gelardi F 

PROVIDER: S-EPMC12248987 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature