Lifetime water arsenic, genetic susceptibility, and bladder cancer in the New England Bladder Cancer Study.

ABSTRACT:

Background

Exposure to arsenic in drinking water may interact with common genetic variants in urinary bladder cancer risk.

Methods

We conducted a gene-environment interaction analysis among 1091 bladder cancer cases and 928 controls from the New England Bladder Cancer Study. Genetic variants tested as effect modifiers included those associated with bladder cancer and arsenic metabolism. Interactions with disease-specific polygenic scores and a genome-wide gene-environment interaction analysis were also conducted. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated with average arsenic concentration (µg/L), average daily arsenic (µg/day), and cumulative arsenic (mg) in water as exposures.

Results

Multiplicative interactions for bladder cancer risk were

SUBMITTER: Pomares-Millan H 

PROVIDER: S-EPMC12249215 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature