High Tumoral CD24 Expression and Low CD3⁺ Tumor-Infiltrating Lymphocytes as a Biomarker for High-Risk Locally Advanced Nasopharyngeal Carcinoma.

ABSTRACT: Introduction: The limited value of TNM staging in locally advanced (LA) nasopharyngeal carcinoma (NPC), defined as stage III or IV NPC, highlights the need for prognostic markers. Here, we aimed to evaluate the ability of the cancer stem cell markers, BMI1, ALDH1, CD44, and CD24, and the epithelial-mesenchymal transition marker, vimentin, as novel prognostic markers in LA-NPC. Methods: A cohort of 83 patients with LA-NPC, previously recruited for another trial with a different goal, was used. The marker expression in tissue sections was evaluated using immunohistochemistry, and the association of expression with survival outcomes was analyzed using the Kaplan-Meier method and Cox regression analysis. Results: The expression of BMI1 and ALDH1 was not associated with sur

SUBMITTER: Ghebeh H 

PROVIDER: S-EPMC12249431 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature