Novel Au(I)- and Ag(I)-NHC Complexes with <i>N</i>-Boc-Protected Proline as Potential Candidates for Neurodegenerative Disorders.

ABSTRACT: Neurodegenerative diseases (NDDs), including Alzheimer's disease (AD) and Parkinson's disease (PD), are characterized by progressive neuronal dysfunction and loss and represent a significant global health challenge. Oxidative stress, neuroinflammation, and neurotransmitter dysregulation, particularly affecting acetylcholine (ACh) and monoamines, are key hallmarks of these conditions. The current therapeutic strategies targeting cholinergic and monoaminergic systems have some limitations, highlighting the need for novel approaches. Metallodrugs, especially ruthenium and platinum complexes, are gaining attention for their therapeutic use. Among metal complexes, gold(I) and silver(I) N-heterocyclic carbene (NHC) complexes exhibit several biological activities, but their application in

SUBMITTER: Ceramella J 

PROVIDER: S-EPMC12249917 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature