An observational study on gray matter volume and white matter integrity in suicide attempters with bipolar I disorder.

ABSTRACT:

Background

Bipolar disorder (BD) is associated with a high risk of lifetime suicide attempts, but relatively few neuroimaging studies have investigated suicidality in the context of BD.

Aim

The study aimed to assess the white matter (WM) integrity and gray matter (GM) volume associated with suicide attempts in BD.

Method

This observational study recruited 32 patients with DSM-5 bipolar I disorder. Group I had multiple (≥2) lifetime suicide attempts, with at least one attempt in the past year. Group II comprised nonattempters/nonideators who screened negative on the C-SSRS-lifetime version. All patients were euthymic (≤8 on 17-item HAM-D; ≤4 on YMRS). Study assessments included a clinical proforma, NIMH-Life Chart Method, and Barratt's Impulsivity Scale (BIS). MR imagi

SUBMITTER: Vishwakarma A 

PROVIDER: S-EPMC12250241 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature