Maternal Phthalate Exposure and Allergic Diseases in Children: A Meta-Analysis and Network Toxicology.

ABSTRACT: Several studies suggest a relationship between phthalates (PAEs) and allergic diseases in children. Therefore, we speculated that PAE exposure may be an important environmental factor causing allergic diseases. The present study employed meta-analysis and network toxicology to analyze the interactions and assess potential pathogenic pathways between prenatal and postnatal PAE exposure and childhood allergic diseases. This study found that prenatal PAEs exposure was positively associated with childhood wheezing and eczema (OR = 1.03, 1.05), and postnatal PAEs exposure was positively associated with childhood wheezing, eczema, and rhinitis (OR = 1.10, 1.05, 1.06). PAE exposure from dust may elicit distinct effects compared to direct exposure to PAEs. Furthermore, a large number of overlappin

SUBMITTER: Xiang Y 

PROVIDER: S-EPMC12250265 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature