Systemic Inflammation and Metabolic Changes After Cardiac Surgery and Postoperative Delirium Risk.

ABSTRACT: Introduction: Postoperative delirium (POD) remains a major complication in geriatric surgical care, with poorly understood molecular mechanisms. Emerging evidence links cardiac surgery to elevated markers of neurologic injury, even in cognitively intact individuals. While neuroinflammation is the prevailing model, a more detailed characterization of the systemic inflammatory and metabolic response to surgery may offer deeper insights into POD pathogenesis. Methods: We used the 7K SomaLogic proteomic platform to analyze preoperative and postoperative day-one serum samples from 78 patients undergoing cardiac surgery with cardiopulmonary bypass. We compared proteomic profiles within individuals (pre- vs. post-surgery) and between those who developed POD and those who did not. Fu

SUBMITTER: Wiredu K 

PROVIDER: S-EPMC12251062 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature