Glucocorticoid use in paediatric posterior fossa tumour surgery and the occurrence of postoperative speech impairment.

ABSTRACT:

Purpose

Postoperative speech impairment (POSI) is a core symptom of cerebellar mutism syndrome (CMS) and is a common complication after the resection of paediatric posterior fossa (PF) tumours. Preoperative glucocorticoids (pGC) are considered standard treatment to reduce tumour oedema; in addition, glucocorticoids are often administered intraoperatively (iGC) to reduce both postoperative nausea and vomiting. The study aims to investigate whether the occurrence of POSI may be associated with pGC and iGC.

Methods

In a prospective observational multicentre study, we included children with a PF tumour requiring either resection or open biopsy. The use of pGC and iGC, including drug type and dose, was registered. Postoperative speech status was classified as mutism, reduced spee

SUBMITTER: Sarup R 

PROVIDER: S-EPMC12254087 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature