Drosophila complement-like Mcr acts as a wound-induced inflammatory chemoattractant.

ABSTRACT: Sterile tissue injury is accompanied by an acute inflammatory response whereby innate immune cells rapidly migrate to the site of injury guided by pro-inflammatory chemotactic damage signals released at the wound. Understanding this immune response is key to improving human health, and recent advances in imaging technology have allowed researchers using different model organisms to observe this inflammatory response in vivo. Over recent decades, offering a unique combination of live time-lapse microscopy and genetics, the fruit fly Drosophila has emerged as a powerful model system to study inflammatory cell migration within a living animal.^1,2,3,4 However, we still know relatively little regarding the identity of

SUBMITTER: Zechini L 

PROVIDER: S-EPMC12254109 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature