Cerebral small vessel disease in memory center patients with dementia with lewy bodies and Alzheimer's disease.

ABSTRACT:

Introduction

Cerebral small vessel disease (CSVD) is a common co-pathology in patients with dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). A comprehensive characterization of CSVD load in DLB and AD patients referred to a memory center is lacking.

Methods

In this retrospective study, we collected data from patients with a clinical DLB diagnosis or clinico-biological AD diagnosis, evaluated at our memory center. They were assessed for CSVD MRI features, including enlarged perivascular spaces (PVS), presence of cerebral amyloid angiopathy (CAA) and hypertensive arteriopathy (HTNA). Differences in CSVD features between AD and DLB and across clinical stages were investigated. Regression models were used to evaluate the association between (i) cerebrovascular risk

SUBMITTER: Bommarito G 

PROVIDER: S-EPMC12254957 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature