Identity by descent and local ancestry mapping of HCV spontaneous clearance in populations of diverse ancestries.

ABSTRACT:

Background

Acute infection with hepatitis C virus (HCV) affects millions of individuals worldwide. Host genetics plays a role in spontaneous clearance of the acute infection which occurs in approximately 30% of the individuals. Common variants in GPR158, genes in the interferon lambda (IFNL) cluster, and the Major Histocompatibility complex (MHC) region have been associated with HCV clearance in populations of diverse ancestry. Fine mapping of those regions has identified some key variants and amino acids as potential causal variants but the role of rare variants in those regions and in the genome, in general, has not been explored. We aimed to detect haplotypes containing rare variants related to HCV clearance using identity-by-descent (IBD) haplotype sharing between unrelated cas

SUBMITTER: Yu Z 

PROVIDER: S-EPMC12255019 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature