Effectiveness of anabolic and anti-resorptive agents for preventing postmenopausal osteoporosis fractures: a systematic review and network meta-analysis.

ABSTRACT:

Background

While anabolic agents are highly effective in stimulating bone formation, their benefits are transient and tend to plateau after prolonged use. This necessitates a transition to anti-resorptive therapies. We aimed to estimate anti-osteoporosis effect and compliance of different anabolic and anti-resorptive agents to explore the optimal cycling strategy.

Methods

PubMed, Embase, Web of Science, and Cochrane Library were searched for randomized controlled trials comparing anabolic or anti-resorptive agents with placebo or each other in postmenopausal women with osteoporosis or osteopenia, reporting outcomes on bone mineral density (BMD) change, fracture incidence, or treatment discontinuation from inception to February 1, 2024. The frequentist random-effect model for

SUBMITTER: Su P 

PROVIDER: S-EPMC12255036 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature