Clinicogenomic Characterization of Inflammatory Breast Cancer.

ABSTRACT:

Purpose

Inflammatory breast cancer (IBC) is a rare and clinically distinct form of breast cancer associated with poor outcomes. The biological mechanisms driving IBC remain poorly understood, partly due to limited large-scale genomic studies that directly compare IBC with non-IBC cases.

Experimental design

We conducted a retrospective analysis of 140 patients with IBC (68 primary tumors and 72 metastatic tumors) and 2,317 patients with non-IBC (700 primary tumors, 65 local recurrences, and 1,552 metastases). We compared clinicopathologic features, single-nucleotide variants, copy-number variants, tumor mutational burden, and exploratory survival outcomes between IBC and non-IBC tumors.

Results

The most frequent somatic alterations in IBC were detected in TP53 (72%), E

SUBMITTER: Priedigkeit N 

PROVIDER: S-EPMC12255483 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature