Anatomical zone and tissue type impacts the repeatability of quantitative MRI parameters and radiomic features for longitudinal monitoring of treatment response in the prostate.

ABSTRACT:

Objective

To (1) establish the repeatability coefficient (%RC) of region of interest (ROI) and voxel-wise measurements of a comprehensive range of quantitative MRI (qMRI) parameters and radiomic features in the prostate, and (2) assess the impact of different tissue types (benign vs tumor) and anatomical zones (peripheral, PZ, and non-peripheral, nPZ) on the %RCs.

Methods

Test-retest qMRI was acquired in ten prostate cancer patients and six healthy volunteers. Parametric maps of apparent diffusion coefficient (ADC), diffusion coefficient (D), perfusion fraction (f), hypoxia score (HS), longitudinal relaxation time (T1), and observed transverse relaxation rate (R2*) were calculated. Fifty-nine radiomic feature maps were calculated from each of the parametric maps and T2-weigh

SUBMITTER: Wang YF 

PROVIDER: S-EPMC12255548 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature