A high proportion of CD38 (high) CD16 (low) NK cells in colorectal cancer can interrupt immune surveillance and favor tumor growth.

ABSTRACT: CD38 + NK cells have been detected in many diseases. The present study investigated the mechanism of CD38 + NK cells in immune surveillance in tumors. Significant increases in the proportions of CD38 + NK cells were detected via flow cytometry in the peripheral blood of patients with breast cancer, colorectal cancer (CRC), esophageal cancer, gastric cancer (GC), lung cancer (LG) or ovarian cancer (OC). Transcriptomics and metabonomics revealed special expression profiles and metabolite abundance patterns in CRC CD38 + NK cells, especially decreased HSPA1 (heat shock 70 kDa protein 1A) and increased ADO (adenosine) levels. Compared with CD38 + NK cells from healthy individuals, CRC CD38 + NK cells presented lower NAD + (nicotinamide adenine dinucleotide) production, apoptosis-inducing abili

SUBMITTER: Wang X 

PROVIDER: S-EPMC12255634 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature