Atypical Actinobacillus pleuropneumoniae serotype 12 strains with a higher virulence potential.

ABSTRACT: Actinobacillus pleuropneumoniae is the causative agent of porcine pleuropneumonia, a disease of major economic impact. Serotype 12 is generally considered to be of low virulence and is typically associated with subclinical infections. However, we describe four atypical serotype 12 field strains recovered from severe clinical outbreaks in Chile. These strains exhibited an unusual toxin gene profile (apxIICA, apxIIICA, apxIBD, apxIIIBD), suggesting the ability to produce both ApxII and ApxIII toxins. Comparative genomic analyses revealed that these atypical strains carry the capsule genes of serotype 12 but the LPS biosynthesis genes of serotype 15, indicating a hybrid genomic structure. Phylogenetic analysis confirmed that they cluster separately from classical serotype 12 strains and are c

SUBMITTER: Vincent AT 

PROVIDER: S-EPMC12255999 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature