Expression of the IL-18-related gene PTX3 correlates with clinicopathological features and prognosis in glioma patients.

ABSTRACT:

Background

Glioma, a highly aggressive brain tumor, presents significant challenges in prognosis and treatment. This study investigates the role of PTX3 expression in glioma and its correlation with patient outcomes, addressing a gap in current research regarding its molecular mechanisms.

Materials and methods

RNA sequencing data and clinical information for glioma patients were obtained from The Cancer Genome Atlas (TCGA). A multigene prognostic signature based on IL-18 signaling-related genes (ISRGs) was constructed using the least absolute shrinkage and selection operator (LASSO) Cox regression method. The functional roles of PTX3 were analyzed through Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Gene Set Enrichment Analysis (GSEA). Single-sampl

SUBMITTER: Wang D 

PROVIDER: S-EPMC12256040 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature