Curcumin promotes spermatogenesis in mice with cryptorchidism by regulating testicular protein <i>O</i>-GlcNAcylation.

ABSTRACT:

Introduction

Curcumin has garnered increasing attention in male reproductive research due to its potential anti-infertility properties. This study aimed to explore the protective effects of curcumin on spermatogenesis impairment in mice with cryptorchidism and to elucidate the underlying mechanisms.

Methods

A total of 56 male Kunming mice aged 10 to 15 days were randomly assigned to different groups, including a control group (BO) and a cryptorchid group with five curcumin treatment groups (CC25, CC50, CC100, CC200, and CC300) receiving varying doses of curcumin (25, 50, 100, 200, and 300 mg/kg, respectively). After five weeks of treatment, evaluations based on organ coefficients, sperm count detection, testicular pathology analysis, and hormone level assessments determined

SUBMITTER: Wang Z 

PROVIDER: S-EPMC12256208 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature