The circadian genes are required in DAL neurons for <i>Drosophila</i> long-term memory formation.

ABSTRACT: We previously showed that memory formation of Drosophila olfactory avoidance can be inhibited by ubiquitous, post-training, inducible disruption of the circadian system. In this report, we limit intervention to the dorsal anterior lateral neurons, cells important for memory formation but not considered a part of the central clock. Post-training induction of "dominant negative" proteins or RNAi directed against either the clock or cycle genes in dorsal anterior lateral neurons disrupts 3-day memory. This experimental design minimizes indirect effects due to abnormal neuronal development, altered sensory processing at the time of training, effects of widespread ectopic expression of inhibiting proteins, and decreases the likelihood of "off-target" effects contributing to

SUBMITTER: Yin JCP 

PROVIDER: S-EPMC12256545 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature