Spatial distribution and subtype-specific expression patterns of Nectin-4 in muscle-invasive bladder cancer.

ABSTRACT:

Objective

To investigate the expression patterns of Nectin-4, the target molecule of the antibody-drug conjugate enfortumab vedotin (EV), in relation to histological and molecular subtypes of urothelial bladder cancer (UBC).

Patients and methods

We assessed the protein expression patterns of Nectin-4 in a spatially organised tissue microarray containing 1386 tissue cores from 314 consecutive patients with UBC who underwent radical cystectomy (2005-2018). Results were correlated with clinicopathological and follow-up data, as well as with different spatial locations (tumour central vs tumour-normal interface and primary tumour vs lymph node [LN] metastases). Additionally, we correlated Nectin-4 expression levels with histological and molecular subtypes. Finally, we assessed t

SUBMITTER: Olah C 

PROVIDER: S-EPMC12256731 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature