CADET: Enhanced transcriptome-wide association analyses in admixed samples using eQTL summary data.

ABSTRACT: A transcriptome-wide association study (TWAS) is a popular statistical method for identifying genes whose genetically regulated expression (GReX) component is associated with a trait of interest. Most TWAS approaches fundamentally assume that the training dataset (used to fit the gene expression prediction model) and target genome-wide association study (GWAS) dataset are from the same ancestrally homogeneous population. If this assumption is violated, studies have shown a marked negative impact on expression prediction accuracy as well as reduced power of the downstream gene-trait association test. These issues pose a particular problem for admixed individuals whose genomes represent a mosaic of multiple continental ancestral segments. To resolve these issues, we present CADET, which enab

SUBMITTER: Head ST 

PROVIDER: S-EPMC12256880 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature