Investigating the Shared Genetic Architecture Between Leukocyte Telomere Length and Prostate Cancer.

ABSTRACT:

Purpose

Evidence of an association between leukocyte telomere length (LTL) and prostate cancer (PCa) is accumulating; however, their shared genetic basis remains unclear.

Materials and methods

Using summary statistics obtained from the genome-wide association study (GWAS), we quantified the global and local genetic correlations between two traits. Subsequently, we identified potential pleiotropic loci, common tissue-enriched regions, and risk gene loci while inferring assumed causal relationships.

Results

Our study demonstrated a global genetic correlation between LTL and PCa (genetic correlation=0.066, p=0.017), which was further confirmed in local genomic regions. Cross-trait GWAS meta-analysis revealed 44 shared loci, including 10 novel pleiotropic single nucleotid

SUBMITTER: Li Z 

PROVIDER: S-EPMC12257324 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature