Engineered dual-functional gold nanoparticles enhance radiosensitization in prostate cancer cells: synergistic action of curcumin and gold.

ABSTRACT: Prostate cancer remains a leading cause of cancer-related mortality in men, with the three main treatment modalities being surgery, chemotherapy, radiotherapy, or a combination depending on the stage. However, the use of radiotherapy is often restricted by dose-limiting toxicity of the organs at risk. To address this challenge, we developed curcumin-coated gold nanoparticles (Curc-GNPs) that leverage both the photoelectric properties of gold and the radiosensitizing effects of curcumin. In this study, we explore the stability, cytotoxicity, cellular uptake, and radio-sensitizing potential of Curc-GNP in PC-3 prostate cancer cells. Curc-GNPs exhibited a biphasic dose-response curve where concentrations up to 100 μg mL^-1 showed minimal cytotoxicity, whereas higher doses (>100 μg m

SUBMITTER: Aborig M 

PROVIDER: S-EPMC12257358 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature