New Generation Modified Azole Antifungals against Multidrug-Resistant <i>Candida auris</i>.

ABSTRACT: The rise of antifungal resistance and limited treatment options highlight the urgent need for new drug classes. Candida auris is a serious global health threat with few effective therapies. In this study, novel azole-based compounds were developed by modifying the azole core with cyclic heteroaliphatic linkers connecting aromatic and heteroaromatic rings. Several compounds showed potent activity against C. auris, including azole-resistant strains, with MICs ranging from 0.016 to 4 μg/mL. The compounds also demonstrated strong activity against C. albicans, Nakaseomyces glabratus, C. tropicalis, and C. parapsilosis, with MICs mostly below 1 μg/mL. Compounds 7, 18, and 21 were more potent than fluconazole. Compound 7 inhibi

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12257509 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature