Genetic diversity of HIV in Yunnan, China: the role of second-generation recombination involving circulating and unique recombinant forms.

ABSTRACT:

Background

The genetic diversity of HIV is significantly influenced by second-generation recombination events involving circulating recombinant forms (CRFs) and unique recombinant forms (URFs), which are crucial for the virus's evolution and dissemination. The China-Myanmar border region is recognized as a focal point for inter-subtype recombination of HIV, with recombinant strains predominating in this area.

Methods

Near full-length HIV genomes were amplified from plasma samples of eight Burmese individuals newly diagnosed with HIV in Baoshan, China, from 2006 to 2020. Phylogenetic trees were constructed using maximum likelihood methods, and Bootscan analysis was conducted to identify recombination structures.

Results

Among the eight sequences, one (YN33F28) clustere

SUBMITTER: Xie YN 

PROVIDER: S-EPMC12257697 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature