First-line Eradication of Helicobacter pylori Infection with High-Dose Amoxicillin and Vonoprazan: A Systematic Review and Meta-analysis.

ABSTRACT:

Background/aims

Due to increasing Helicobacter pylori resistance, the effectiveness of proton pump inhibitor-based regimens has diminished. There is a need to assess the high-dose amoxicillin (≥3 g/day) and vonoprazan dual therapy through meta-analysis to determine if it is more effective than previous protocols.

Materials and methods

A computer search of PubMed, Web of Science, Cochrane Library, Embase, and ClinicalTrials.gov was carried out to identify randomized controlled trials of massive dose amoxicillin and vonoprazan double treatment for H. pylori infection, up to June 2023. The primary outcome measures were the eradication rate and adverse event rate.

Results

A total of 7 studies encompassing 2601 patients were analyzed. The eradication rate of the high-dose

SUBMITTER: Yu H 

PROVIDER: S-EPMC12257729 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature