Effects of letrozole combined with clomiphene in the treatment of polycystic ovary syndrome: a meta-analysis.

ABSTRACT:

Background

PCOS is a common endocrine gynecological disorder, and its associated hormonal abnormalities and ovulatory dysfunction are leading causes of infertility. Ovulation induction is considered a fundamental treatment for PCOS patients. Clomiphene and letrozole are currently widely used ovulation-inducing agents. This study employs meta-analysis to comprehensively and systematically evaluate the clinical efficacy and adverse effects of letrozole combined with clomiphene in the treatment of PCOS.

Objective

The aim of this study is to compare the clinical efficacy and adverse effects of letrozole combined with clomiphene in the treatment of PCOS, providing a theoretical basis for therapeutic decision-making.

Methods

RCTs on letrozole combined with clomiphene for PC

SUBMITTER: Du B 

PROVIDER: S-EPMC12257732 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature