Non-linear association between metabolic score for insulin resistance and nonalcoholic fatty liver disease: analysis of US National health and nutrition examination survey data, 2017-2020.

ABSTRACT:

Background

Although the metabolic score for insulin resistance (METS-IR) is significantly associated with metabolic disorders, its dose-response relationship with nonalcoholic fatty liver disease (NAFLD) remains inconclusive. This study aimed to investigate the dose-response relationship between the metabolic score for insulin resistance and NAFLD, and to identify its inflection point.

Methods

This cross-sectional study evaluated the association between METS-IR and NAFLD using multivariable logistic regression applied to data from the 2017-2020 US National Health and Nutrition Examination Survey. Non-linear dynamics were investigated through smoothing spline models and segmented regression. Subgroup comparisons were performed, and diagnostic accuracy was assessed using inter

SUBMITTER: Wang S 

PROVIDER: S-EPMC12257790 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature