Epigenetic age and fertility timeline: testing an epigenetic clock to forecast in vitro fertilization success rate.

ABSTRACT:

Background

In the field of in vitro fertilization (IVF), the search for reliable success predictors is ongoing, with novel biomarkers gaining increasing attention. Epigenetic clocks, mathematical models based on DNA methylation (DNAm) patterns, have revolutionized aging research by providing insights into biological aging. However, the magnitude of the benefit of the use of a simplified and non-specific epigenetic clock is still insufficient to claim for its clinical use. We investigated the potential role of epigenetic clocks in predicting IVF success.

Methods

This prospective observational study involved 379 women of reproductive age who underwent IVF treatment. On the day of recruitment, blood samples were collected, and genomic DNA was isolated from white blood cells. Ep

SUBMITTER: Marinello D 

PROVIDER: S-EPMC12257822 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature