Chronic Nanoplastic Exposure Promotes the Development and Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease.

ABSTRACT:

Background and aims

Plastic particles are a global pollution problem, and humans are potentially exposed to them. Ingested plastic particles, microparticles (MPs) and nanoparticles (NPs), predominantly accumulate in the liver and cause hepatotoxicity through oxidative stress and metabolic dysfunction. NPs promote more toxic actions than MPs; however, the mechanisms involved in developing and progressing metabolic dysfunction-associated steatotic liver disease (MASLD) from chronic exposure to NPs remain poorly understood. Hedgehog (Hh) signalling regulates MASLD pathogenesis. Herein, we investigated the pathophysiological effects of NPs in MASLD.

Methods

Mice were orally administered NPs via drinking water while fed a choline-deficient, L-amino acid-defined, high-fat diet (CD

SUBMITTER: Han J 

PROVIDER: S-EPMC12257899 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature