Neurodevelopment and Growth 2 Years After Probiotic Supplementation in Extremely Preterm Infants: A Randomised Trial.

ABSTRACT:

Aim

To assess neurodevelopment and growth at 2 years corrected age in children born extremely preterm, supplemented with Limosilactobacillus reuteri or placebo.

Methods

Design: Secondary analysis of register data after randomised double-blind placebo-controlled trial.

Setting

Inclusion at two neonatal intensive care units in Sweden. Local follow-up per national guidelines.

Subjects

134 infants born at 23-27 weeks' gestation with a birth weight < 1000 g.

Intervention

Daily enteral supplementation with placebo or Limosilactobacillus reuteri DSM 17938 (2.5 × 10⁸ colony forming units), from within 72 h after birth to postmenstrual week 35-36.

Main outcome measures

Bayley-III developmental assessment and auxology at 24 ± 3 months corrected a

SUBMITTER: Wejryd E 

PROVIDER: S-EPMC12258099 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature