Genomic organization, domain assortments, and nucleotide-binding domain diversity of NLR proteins in Sordariales fungi.

ABSTRACT: Fungi have NOD-Like receptors (NLRs), homologous to the innate immune receptors found in animals, plants and bacteria. Fungal NLRs are characterized by a great variability of domain organizations, but the identity of the nucleotide-binding domains, the genomic localization, and the factors associated with variation in the composition of repertoires of fungal NLRs are not yet fully understood. To better understand the variability of fungal NLR repertoires and the underlying determinants, we conducted a thorough analysis of genome data from the ascomycete order Sordariales. Using similarity searches based on hidden Markov models profiles for canonical N-terminal, nucleotide-binding, or C-terminal domains, we characterized 4613 NLRs in 82 Sordariales taxa. By examining the Helical Third secti

SUBMITTER: Bonometti L 

PROVIDER: S-EPMC12258605 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature