Characterising the association between posterior parietal metabolite levels and cortical macrostructure in a cohort spanning childhood to adulthood.

ABSTRACT: Postnatal brain development is characterised by dynamic macrostructural changes, including cortical thinning and cortical flattening during childhood and adolescence. These macro-structural changes are parallel with developmental changes in brain neurochemistry, probed in the human brain using Magnetic Resonance Spectroscopy (MRS). This includes neurotransmitters such glutamate and gamma-aminobutyric acid (GABA), as well as building blocks of neuronal and associated tissue such as N-acetyl aspartate (NAA), and those involved in metabolism such as creatine (Cr). While previous research has linked MRS-measured neuro-metabolite levels to bulk tissue composition (e.g., gray matter, white matter, and cerebrospinal fluid), the relationship between neurochemistry and more granular macrostructural

SUBMITTER: Thomson AR 

PROVIDER: S-EPMC12258735 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature