Molecular Epidemiology and evolutionary characteristics of dengue virus serotype-2 strains in Sri Lanka.

ABSTRACT:

Background

Surveillance and characterization of different dengue virus (DENV) lineages of different serotypes causing outbreaks is crucial for initiation of timely dengue control measures and for implementing dengue vaccines. Therefore, we characterized the DENV-2 strains in Sri Lanka from 2016, until end of 2023 and their evolutionary dynamics to understand the geographical spread and mutations arising with the DENV-2 serotypes in Sri Lanka.

Methodology

Sequencing was carried out on 80 DENV-2 samples collected from patients with acute dengue recruited from 2016 to 2018 and 12 DENV-2 samples from 2022 to 2023 using Oxford Nanopore Technology. Phylogenetic analysis was carried out using the IQ-TREE tool within Galaxy to construct a phylogenetic tree from the aligned sequence

SUBMITTER: Ariyaratne D 

PROVIDER: S-EPMC12258741 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature