Functional variants in the TAS2R38 bitter taste receptor associate with postprandial glycemia.

ABSTRACT:

Aims/hypothesis

Functional variants in the TAS2R38 bitter taste receptor influence bitter taste perception and inform dietary and lifestyle behaviors that impact glucose homeostasis. Experimental data suggest that TAS2R38 receptors also mediate postprandial GLP-1 secretions from intestinal L-cells, though human study data are limited. To further establish the role of TAS2R38 in glucose homeostasis in humans, we tested whether functional variants conferring greater TAS2R38 sensitivity associate with lower blood glucose, particularly in the postprandial state, independent of dietary- and lifestyle-mediated effects of TAS2R38 on glucose levels.

Methods

We analyzed participants without type 2 diabetes of European ancestry in the UK Biobank. We used known functional variants in <

SUBMITTER: Gervis JE 

PROVIDER: S-EPMC12258749 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature