A Proof-of-Concept Clinical Trial Design for Evolutionary Guided Precision Medicine for Cancer.

ABSTRACT: Current Precision Medicine (CPM) matches cancer therapies to consensus molecular characteristics at one or more timepoints. However, cancers contain extensive subclonal heterogeneity leading to dynamic evolution in response to therapy. Mathematical modeling has the potential to optimize timing and sequencing of therapies in a more effective and personalized manner than CPM. Clinical trial designs testing Evolutionary Guided Precision Medicine (EGPM) strategies for preventing or delaying relapse to improve outcomes, are needed. In a simulation, we evaluated Dynamic Precision Medicine (DPM), an EGPM, in a stratified randomized design based on whether the patient was predicted to benefit from DPM, using an evolutionary classifier. We present this new proof-of-concept clinical trial design and

SUBMITTER: Parashar D 

PROVIDER: S-EPMC12258754 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature