Executive dysfunction relates to salience network desegregation in behavioral variant frontotemporal dementia.

ABSTRACT:

Background

The organization of the brain into distinct networks increases (i.e., differentiation) during development and decreases (i.e., de-differentiation) during healthy aging, changes that are associated with improvements and worsening of cognition, respectively. Given that behavioral variant frontotemporal degeneration (bvFTD) is a neurodegenerative disease associated with executive dysfunction and selective vulnerability of the salience network, we tested the hypotheses that bvFTD structural networks are de-differentiated compared to cognitively normal controls (CNC) and that network de-differentiation relates to worse executive function.

Methods

In a sample of 90 patients with bvFTD and 71 age-matched CNC with diffusion MRI data we generated probabilistic tractography

SUBMITTER: Matyi MA 

PROVIDER: S-EPMC12258773 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature