Concurrent multimodal imaging demonstrates that EEG-based excitation/inhibition balance reflects glutamate and GABA concentrations.

ABSTRACT: Neural excitation/inhibition (E/I) ratio is dynamically regulated on multiple timescales. Adaptive changes in E/I ratio can support healthy development, learning, and cognition, while disordered E/I ratio has been implicated in neurodevelopmental disorders, neurodegenerative disorders, and states of impaired vigilance. There has been growing interest in inferring E/I ratio from efficient and noninvasive measurements such as electroencephalography (EEG), and several algorithms have been proposed to estimate E/I ratio from EEG. Despite promising results, there has been a lack of validation studies testing the underlying neurochemical changes leading to increased or decreased EEG-based E/I ratio. Here, using concurrent EEG and magnetic resonance spectroscopy (MRS) for over an hour, we assesse

SUBMITTER: Cochrane A 

PROVIDER: S-EPMC12258876 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature