Multivariate Resting-State Functional Connectivity Features Linked to Transdiagnostic Psychopathology in Early Psychosis.

ABSTRACT:

Background

Early psychosis (EP) is characterized by neurobiological changes, including alterations in resting-state functional connectivity (RSFC). We now understand that symptoms and neural changes may overlap across EP diagnostic categories. However, the relationship between RSFC patterns and transdiagnostic symptom dimensions remains poorly understood.

Methods

We employed Partial Least Squares correlation to examine multivariate relationships between whole-brain RSFC and clinical symptoms in 124 EP patients (aged 16-35 years) diagnosed with schizophrenia, schizoaffective disorder, or a psychotic mood disorder. RSFC was computed among 216 cortical and subcortical regions. Clinical assessment included 41 symptom measures spanning positive, negative, general psychopathology,

SUBMITTER: Wang HR 

PROVIDER: S-EPMC12258889 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature