Genotype-Specific Electroretinogram Signatures in <i>Drosophila</i>: Implications for Neurodegeneration Models Using <i>w</i> ^<i>1118</i> Backgrounds.

ABSTRACT: Drosophila melanogaster serves as a powerful model for studying neurodegenerative diseases, often employing the GAL4-UAS system for targeted gene expression. Electroretinograms (ERGs) provide a robust in vivo functional readout of neuronal integrity and are increasingly used to assess disease progression and therapeutic interventions in these models. However, the genetic background upon which these models are built, particularly the widely used w ¹¹¹⁸ white-eyed mutant, can significantly influence baseline ERG characteristics. This study systematically characterizes ERG responses in wild-type Canton S (CS), w ¹¹¹⁸ , and a w ¹¹¹⁸ line carrying a UAS-hPLD1 construct (which includes a mini-white gene). We

SUBMITTER: Manuel N 

PROVIDER: S-EPMC12258897 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature