Adolescent alcohol consumption alters sex-specific behaviors associated with prefrontal functional connectivity in mice.

ABSTRACT: The prefrontal cortex (PFC) is one of the last brain regions to fully mature, making it particularly sensitive to stress and drug use early in life. Both human and rodent studies find long-lasting behavioral changes after adolescent alcohol exposure that implicate underlying disruptions in PFC development, including structural abnormalities and altered brain functional connectivity. Few rodent studies have been conducted to understand the network-level implications of these disruptions. We assessed how adolescent binge-like alcohol consumption in a drinking in the dark (DID) model affected adult aversion-resistant alcohol consumption, exploration, and brain-wide functional connectivity in mice. Approximately one month after the conclusion of DID, only female mice exposed to alcohol during

SUBMITTER: Seemiller LR 

PROVIDER: S-EPMC12258943 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature