Nucleus accumbens neuron subtype translatome signatures in socially stressed females.

ABSTRACT:

Background

The nucleus accumbens (NAc) is a reward circuitry hub associated with major depressive disorder (MDD) and chronic stress in rodents. While transcriptional adaptations in NAc medium spiny neuron (MSN) subtypes, those enriched in dopamine receptor 1(D1) or dopamine receptor 2 (D2) and adenosine 2a receptor (A2A) are well characterized in socially stressed male rodents, there is less knowledge of MSN subtype adaptations in socially stressed females.

Methods

Chronic witness defeat stress (CWDS) was performed in female D1-Cre-RiboTag and A2A-Cre-RiboTag mice. After stress, mice were separated into high- and low-social interactors with a three Chamber Social Interaction test. Following isolation of ribosome-associated mRNA, MSN subtype-specific gene expression profiles

SUBMITTER: Kumar G 

PROVIDER: S-EPMC12258951 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature