Test-retest reliability of multi-metabolite edited MRS at 3T using PRESS and sLASER.

ABSTRACT:

Purpose

Spectral editing is the most common MRS approach for noninvasive in vivo measurement of low-concentration, strongly overlapped metabolites in the brain, such as γ-aminobutyric acid (GABA) and glutathione (GSH). Multi-metabolite editing methods, including HERMES and HERCULES, have recently been introduced, where multiple J-coupled metabolites can be edited in a single acquisition without increasing total scan time. Yet little is known regarding the reliability of these methods. This study assessed the test-retest reliability of HERMES and HERCULES, where volume localization was achieved using either PRESS or sLASER.

Methods

Sixteen healthy adult volunteers were scanned twice in two separate sessions. Single-voxel edited MRS data were acquired in the medial pari

SUBMITTER: Archibald J 

PROVIDER: S-EPMC12259001 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature