Acute induction of IFNα is responsible for the attenuation of the live measles vaccine.

ABSTRACT: The live-attenuated measles vaccine (LAMV) protects against measles in a safe, efficacious and durable manner. However, the mechanism by which LAMV is attenuated is not well understood, contributing to the increased vaccine hesitancy that has caused a worldwide resurgence of measles. Here, we provide a molecular model of attenuation that implicates increased host innate immune responses and increased LAMV susceptibility to those responses. Our study leverages both in vitro and in vivo models of infection to find that acute induction of innate immunity in immune cells is the critical determinant of LAMV attenuation. We show that LAMV, in contrast to pathogenic wild type measles virus (MeV), causes a strong IFNα response in primary human peripheral blood mononuclear cells, whic

SUBMITTER: Edwards JM 

PROVIDER: S-EPMC12259043 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature