Prenatal Zika Virus Exposure Disrupts Social-Emotional Development and Cortical Visual Function in Infant Macaques.

ABSTRACT: Prenatal exposure to Zika virus (ZIKV) results in a spectrum of outcomes, ranging from severe birth defects and early childhood developmental delays to no apparent deficits. However, the mechanisms underlying these outcomes, particularly in the context of different maternal infection conditions, remain poorly defined. In this study, we employed a translational rhesus macaque model of prenatal ZIKV infection to evaluate longitudinal visual and auditory development from 1 to 12 months of age and characterize neurodevelopmental outcomes at 12 months. Pregnant macaques, either flavivirus-naive or with prior dengue virus (DENV) exposure, were inoculated in the first trimester (~30 or 45 gestational days) with an Asian or African lineage of ZIKV or received a saline injection as controls. Matern

SUBMITTER: Ausderau KK 

PROVIDER: S-EPMC12259048 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature