<i>Mycobacterium tuberculosis</i> effector protein PE5 hijacks the host CRL2 ubiquitin ligase complex.

ABSTRACT: Mycobacterium tuberculosis (Mtb) is the leading infectious killer and infects one quarter of the global population. During infection, Mtb evade host immune responses via secreted effector proteins that interfere with, modulate, and protect from potent antibacterial responses. One such class of mycobacterial effector proteins are the PE/PPE proteins, a huge family of proteins encoded by an impressive 10% of the Mtb genome. Because some PE/PPEs have demonstrated roles in immune regulation and host cell interaction, and because of the sheer number of PE/PPEs in pathogenic mycobacteria (~170-200+ members depending on the species), they are thought to contribute to Mtb virulence and pathogenesis. However, the cellular functions of Mtb's 169 PE/PPE proteins have yet to be comprehensively

SUBMITTER: Madduri BTSA 

PROVIDER: S-EPMC12259106 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature