Inflammatory Crosstalk Between Rotator Cuff Tissues is Altered with Age and Sex.

ABSTRACT: Musculoskeletal disorders, particularly those affecting the shoulder, are a significant health concern, especially in aging populations. Nevertheless, the initiating factors of joint degeneration remain poorly understood. Research has primarily focused on age-related changes in individual musculoskeletal tissues, with limited investigation into the complex interactions between tissues. Recent studies on interorgan communication between musculoskeletal tissues and other organs have gained attention, but local interactions within the shoulder remain underexplored. This study aims to investigate age- and sex-related differences in bone-tendon-muscle (BTM) crosstalk, hypothesizing that these interactions vary by age and sex, with older and female tissues exhibiting a reduced secretory phenotyp

SUBMITTER: Kalco H 

PROVIDER: S-EPMC12259124 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature